The effect of citrulluscolocynthis on blood glucose profile level in diabetic rabbits

Introduction: Diabetes is one of the most common diseases in this century. To cure this illness, herbal plants as well as medicine and diet therapy are used. This study is designed to determine the effect of citrullus colocynthis fruit pulp and seed on blood glucose in diabetic rabbits. Material and Methods: This experimental study was conducted on 36 white male New Zealand rabbits in animal laboratory of Tabriz University of Medical Sciences in 2006.To determine the effect of citrullus colocynthis fruit on blood glucose, we used the pulp and seed extracts of citrullus colocynthis. Blood glucose was measured using enzymatic kit via Elan Auto Analyzer. The results were analyzed in SPSS software. Results: 100 mg/kg B.W of the pulp and seed extracts of citrullus colocythis significantly decreased blood glucose as compared to the diabetic control group. Conclusion: The results suggest that citrullus colocythis extract can probably decrease the blood glucose in diabetic rabbits, but further studies are necessary for finding the probable side-effects and also its appropriate and safe dose.